反应详情

Pentane-1,2,5-triol (5.00 g) was dissolved in acetone (150 mL), 2,2-dimethoxypropane (10.5 mL) and 4-methylbenzenesulfonic acid (794 mg) were added, and the mixture was stirred at room temperature for 1.5 hrs. The reaction mixture was concentrated under reduced pressure, and the residue was separated and purified by silica gel column chromatography (eluent, hexane:ethyl acetate=80:20→50:50) to give the title compound (3.79 g) as a colorless oil.

1. concentrationThe reaction mixture was concentrated under reduced pressure
2. customthe residue was separated
3. custompurified by silica gel column chromatography (eluent, hexane:ethyl acetate=80:20→50:50)