反应详情

To a flask were added 2.0 g 2-mercapto-5-methylbenzimidazole, 4.2 g potassium carbonate, 30 ml N,N-dimethylformamide and 3.9 g benzyl chloride. The reaction mixture was heated to 60 C for 16 hours, then cooled to 50 C and quenched with 60 ml water and cooled to 5 C. The solid was filtered and washed with water and then recrystallized by dissolving in 50 ml hot acetonitrile and adding 10 ml of water. After cooling to 5 C, the product was filtered, washed and dried resulting in 3.5 g white solid as a mixture of the 5-methyl and 6-methyl isomers.

1. temperatureThe reaction mixture was heated to 60 C for 16 hours
2. temperaturecooled to 50 C
3. customquenched with 60 ml water
4. temperaturecooled to 5 C
5. filtrationThe solid was filtered
6. washwashed with water
7. customrecrystallized
8. dissolutionby dissolving in 50 ml hot acetonitrile
9. additionadding 10 ml of water
10. temperatureAfter cooling to 5 C
11. filtrationthe product was filtered
12. washwashed
13. customdried