Methyl Acrylate → HCID 22182165, compound

HRID 1926561Notes

Reaction equation

HRID 1926561 reaction equation
[CH2:1]1[O:3][CH:2]1[CH2:4][OH:5].[C:6]([O:10]C)(=[O:9])[CH:7]=[CH2:8]>CC(OC)(C)C>[CH2:1]1[O:3][CH:2]1[CH2:4][OH:5].[C:6]([O-:10])(=[O:9])[CH:7]=[CH2:8]

Participants

4

Reactant 2

HCID 7294Methyl AcrylateHCID 11164Glycidol

Product 1

HCID 22182165HCID 22182165, compound

Reagents, catalysts & solvents 1

HCID 15413tert-Butyl methyl etherSolvent

Procedure

In a screw-top glass container, in each case 5 mMol of glycidol (370 mg) were agitated with 10 or 50 mMol of methyl acrylate, 50 mg of Novozym® 435 (supported lipase from Candida antarctica B, from Novozymes, Denmark), 5.0 ml of MTBE (tert-butyl methyl ether) and, in some cases, 1.0 g of 5 Å molecular sieve at 20 or 40° C. for 24 h. Thereafter, the enzyme was filtered off and the excess of methyl acrylate was removed on a rotary evaporator. A colorless acrylate was obtained.

Workup

  1. filtrationThereafter, the enzyme was filtered off
  2. customthe excess of methyl acrylate was removed on a rotary evaporator

Sources & evidence

ORD record
ord-94dd04f5e0864d3bb63dafb962cbb37c
Source dataset
uspto-grants-2012_05
Patent number
US08183018B2

Reaction notes

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