反应详情

Suspend 50 g (235.6 mmol) 6-phenylfuro[2,3-d]pyrimidin-4(3H)-one at RT in 375 ml (4023 mmol) phosphoryl chloride and heat the mixture to boiling (evolution of HCl). After 1 h, cool the dark solution to RT and add dropwise to a vigorously stirred mixture of 1.25 litre water and 2.25 litre conc. ammonia solution (25 wt. %) (heating to 55-75° C., pH>9). At the end of addition, cool to RT and extract the mixture three times with 1.6 litre dichloromethane each time. Combine the organic phases, dry, and concentrate by vacuum evaporation. Stir the residue with diethyl ether, filter with suction, and dry at high vacuum. 47.3 g (87% of theor.) of the target compound is obtained.

1. customat RT
2. temperatureheat the mixture
3. additionAt the end of addition
4. temperaturecool to RT
5. extractionextract the mixture three times with 1.6 litre dichloromethane each time
6. customdry
7. concentrationconcentrate by vacuum evaporation
8. filtrationfilter with suction
9. customdry at high vacuum
10. custom47.3 g (87% of theor.) of the target compound is obtained