反应详情

温度

160 °C

Heat 2.0 g (8.67 mmol) 4-chloro-6-phenylfuro[2,3-d]pyrimidine and 6.04 ml (34.7 mmol) DIEA in 5 ml DMF to 160° C. Add 3.15 g (17.34 mmol) 6-aminohexanoic acid methyl ester hydrochloride and stir for 4 h at 160° C. After cooling, add the mixture to ice water and extract three times with ethyl acetate. Combine the organic phases and wash with saturated ammonium chloride solution, dry over magnesium sulphate and concentrate under vacuum. Add methanol to the oil residue. Filter off the precipitated solid with suction, wash with methanol again and dry the solid at high vacuum. 1.85 g (57.2% of theor.) of the target compound is obtained.

1. temperatureAfter cooling
2. extractionextract three times with ethyl acetate
3. washwash with saturated ammonium chloride solution
4. dry with materialdry over magnesium sulphate
5. concentrationconcentrate under vacuum
6. filtrationFilter off the precipitated solid with suction
7. washwash with methanol again
8. customdry the solid at high vacuum
9. custom1.85 g (57.2% of theor.) of the target compound is obtained