反应详情

Add 1.15 g (8.9 mmol) DIEA and 0.67 g (5.9 mmol) 6-aminocapronitrile to 1.0 g (3.0 mmol) 4-chloro-5-(4-methoxyphenyl)-6-phenylfuro[2,3-d]pyrimidine in 10 ml DMF and heat for 2 h to 120° C. After cooling, add water to the mixture and extract three times with ethyl acetate. Wash the organic phase with water, with dilute hydrochloric acid and with saturated sodium chloride solution, dry, and concentrate by evaporation. 1.2 g (98% of theor.) of a yellow oil is obtained, and is used as the raw product in further reactions.

1. temperatureheat for 2 h to 120° C
2. temperatureAfter cooling
3. extractionextract three times with ethyl acetate
4. washWash the organic phase with water
5. dry with materialwith dilute hydrochloric acid and with saturated sodium chloride solution, dry
6. concentrationconcentrate by evaporation
7. custom1.2 g (98% of theor.) of a yellow oil is obtained