反应详情

Put 12.118 g (100 mmol) N-methylbenzylamine with 16.584 g (120 mmol) potassium carbonate in 100 ml toluene. Add dropwise 11.103 g (120 mmol) chloroacetone and stir overnight under reflux. Then cool to RT, filter to remove the salt and concentrate by evaporation. Purify the residue by chromatography on silica gel (solvent: cyclohexane/ethyl acetate 8:2), obtaining 9.0 g (50.8% of theor.) of the target compound.

1. temperatureunder reflux
2. filtrationfilter
3. customto remove the salt
4. concentrationconcentrate by evaporation
5. customPurify the residue by chromatography on silica gel (solvent: cyclohexane/ethyl acetate 8:2)
6. customobtaining 9.0 g (50.8% of theor.) of the target compound