N,N-Diethylaniline → 4-Chloro-5-(4-methoxyphenyl)furo[2,3-d]pyrimidine
Reaction equation
C(N(CC)C1C=CC=CC=1)C.[CH3:12][O:13][C:14]1[CH:19]=[CH:18][C:17]([C:20]2[C:28]3[C:27](=O)[NH:26][CH:25]=[N:24][C:23]=3[O:22][CH:21]=2)=[CH:16][CH:15]=1.P(Cl)(Cl)([Cl:32])=O>C1(C)C=CC=CC=1>[Cl:32][C:27]1[C:28]2[C:20]([C:17]3[CH:18]=[CH:19][C:14]([O:13][CH3:12])=[CH:15][CH:16]=3)=[CH:21][O:22][C:23]=2[N:24]=[CH:25][N:26]=1Participants
Conditions
- Temperature
- 100 °C
Procedure
Add 14.5 ml (13.6 g, 90.8 mmol) N,N-diethylaniline to a suspension of 10.0 g (41.3 mmol) 5-(4-methoxyphenyl)furo[2,3-d]pyrimidin-4(3H)-one in 250 ml toluene and heat to 100° C. At this temperature, add 4.2 ml (7.0 g, 45.4 mmol) phosphoryl chloride dropwise, and stir the reaction mixture for 15 h at 100° C. Then add a further 1.2 ml (2.0 g, 13 mmol) phosphoryl chloride and stir the reaction mixture again for 22 h at 100° C. After cooling to room temperature, quickly wash the reaction solution with, successively, 250 ml ice water, twice with 250 ml cold 20% sodium hydroxide solution each time, again with 250 ml ice water, 250 ml satd. sodium chloride solution, 1 N hydrochloric acid and 250 ml ice water. Dry the organic phase over sodium sulphate, filter and concentrate by vacuum evaporation. 6.3 g (59% of theor.) of the title compound is obtained.
Workup
- stirringstir the reaction mixture again for 22 h at 100° C
- temperatureAfter cooling to room temperature
- washquickly wash the reaction solution with, successively, 250 ml ice water
- dry with materialDry the organic phase over sodium sulphate
- filtrationfilter
- concentrationconcentrate by vacuum evaporation
Sources & evidence
- ORD record
- ord-b72774a25f7145fabf6e6be97d61cd41
- Source dataset
- uspto-grants-2012_05
- Patent number
- US08183246B2
Reaction notes
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