Tetrahydrofuran → HCID 69082425, compound

HRID 1926917Notes

Reaction equation

HRID 1926917 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[C:17]3[C:16]([NH:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][C:24]([OH:26])=[O:25])=[N:15][CH:14]=[N:13][C:12]=3[O:11][C:10]=2[C:27]2[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=2)=[CH:5][CH:4]=1.C1COCC1.[OH-].[Na+:39]>CO.O>[Na+:39].[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]([C:9]2[C:17]3[C:16]([NH:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][C:24]([O-:26])=[O:25])=[N:15][CH:14]=[N:13][C:12]=3[O:11][C:10]=2[C:27]2[CH:28]=[CH:29][CH:30]=[CH:31][CH:32]=2)=[CH:7][CH:8]=1

Participants

6

Reactant 3

HCID 8028TetrahydrofuranHCID 14798Sodium HydroxideHCID 23627862HCID 23627862, compound

Product 1

HCID 69082425HCID 69082425, compound

Reagents, catalysts & solvents 2

HCID 962WaterCatalystHCID 887MethanolSolvent

Procedure

Dissolve 200 mg (0.464 mmol) 6-{[5-(4-methoxyphenyl)-6-phenylfuro[2,3-d]pyrimidin-4-yl]amino}hexanoic acid at RT in 0.75 ml methanol, 0.5 ml THF and a few drops of water, and add 0.464 ml 1 N sodium hydroxide solution. Stir the mixture for 5 min, then concentrate by vacuum evaporation and dry the residue at high vacuum. 221 mg of the target compound is obtained.

Workup

  1. concentrationconcentrate by vacuum evaporation
  2. customdry the residue at high vacuum

Sources & evidence

ORD record
ord-cd789f13d0404f4f925aff138f2c5da6
Source dataset
uspto-grants-2012_05
Patent number
US08183246B2

Reaction notes

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