Trifluoroacetic acid → HCID 25096162, compound

HRID 1926938Notes

Reaction equation

HRID 1926938 reaction equation
C([O:5][C:6](=[O:38])[CH2:7][O:8][CH2:9][C:10]([CH3:37])([CH3:36])[CH2:11][O:12][C:13]1[C:14]2[C:21]([C:22]3[CH:27]=[CH:26][C:25]([O:28][CH3:29])=[CH:24][CH:23]=3)=[C:20]([C:30]3[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=3)[O:19][C:15]=2[N:16]=[CH:17][N:18]=1)(C)(C)C.FC(F)(F)C(O)=O>ClCCl>[CH3:29][O:28][C:25]1[CH:24]=[CH:23][C:22]([C:21]2[C:14]3[C:13]([O:12][CH2:11][C:10]([CH3:37])([CH3:36])[CH2:9][O:8][CH2:7][C:6]([OH:38])=[O:5])=[N:18][CH:17]=[N:16][C:15]=3[O:19][C:20]=2[C:30]2[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=2)=[CH:27][CH:26]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 25096161HCID 25096161, compound

Product 1

HCID 25096162HCID 25096162, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Put 280 mg (0.54 mmol) (3-{[5-(4-methoxyphenyl)-6-phenylfuro[2,3-d]pyrimidin-4-yl]oxy}-2,2-dimethylpropoxy)acetic acid tert.-butyl ester in 8 ml dichloromethane. Add 2 ml trifluoroacetic acid and stir for 1 h at RT. Then concentrate by evaporation and mix the residue with petroleum ether. Filter the solid on a frit with suction, and dry at high vacuum. 220 mg (88.1% of theor.) of the target compound is obtained.

Workup

  1. concentrationThen concentrate by evaporation
  2. additionmix the residue with petroleum ether
  3. filtrationFilter the solid on a frit with suction
  4. customdry at high vacuum
  5. custom220 mg (88.1% of theor.) of the target compound is obtained

Sources & evidence

ORD record
ord-78774a0a0f184132b318dcb9665ce1f1
Source dataset
uspto-grants-2012_05
Patent number
US08183246B2

Reaction notes

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