反应详情

Dissolve 45 mg (0.10 mmol) 6-{[6-(2-ethylphenyl)-5-(4-methoxyphenyl)furo[2,3-d]pyrimidin-4-yl]amino}hexanoic acid methyl ester in 2.0 ml dioxan and add 0.5 ml 1 N sodium hydroxide solution. Stir for 16 h at RT, then add 0.5 ml 1 N hydrochloric acid and 5 ml ethyl acetate. Separate the organic phase, dry over sodium sulphate, filter and concentrate by evaporation. 38 mg (87% of theor.) of the target compound is obtained.

1. customSeparate the organic phase
2. dry with materialdry over sodium sulphate
3. filtrationfilter
4. concentrationconcentrate by evaporation
5. custom38 mg (87% of theor.) of the target compound is obtained