Lithium hydroxide, monohydrate → HCID 59443594, compound

HRID 1927670Notes

Reaction equation

HRID 1927670 reaction equation
O.[OH-].[Li+].[CH3:4][N:5]([CH3:26])[S:6]([N:9]1[CH:13]=[C:12]([CH2:14][C:15]([CH3:19])([CH3:18])[CH2:16][CH3:17])[N:11]=[C:10]1[CH2:20][CH2:21][C:22]([O:24]C)=[O:23])(=[O:8])=[O:7]>O.CO.C1COCC1>[CH3:26][N:5]([CH3:4])[S:6]([N:9]1[CH:13]=[C:12]([CH2:14][C:15]([CH3:19])([CH3:18])[CH2:16][CH3:17])[N:11]=[C:10]1[CH2:20][CH2:21][C:22]([OH:24])=[O:23])(=[O:7])=[O:8]

Participants

6

Reactant 2

HCID 168937Lithium hydroxide, monohydrateHCID 68672466HCID 68672466, compound2×

Product 1

HCID 59443594HCID 59443594, compound

Reagents, catalysts & solvents 3

HCID 887MethanolSolventHCID 962WaterSolventHCID 8028TetrahydrofuranSolvent

Procedure

A solution of lithium hydroxide monohydrate (182 mg, 4.3 mmol) in water (1.5 mL) was added to a solution of methyl 3-[1-[(dimethylamino)sulfonyl]-4-(2,2-dimethylbutyl)-1H-imidazol-2-yl]propanoate (for synthesis see intermediate 25) (500 mg, 1.4 mmol) in methanol (1.6 mL) and THF (1.6 mL). After stirring at rt overnight, the reaction mixture was concentrated and 2M hydrochloric acid was added. The resulting reaction mixture was concentrated to dryness to afford the title compound, which was used without further purification.

Workup

  1. concentrationthe reaction mixture was concentrated
  2. addition2M hydrochloric acid was added
  3. customThe resulting reaction mixture
  4. concentrationwas concentrated to dryness

Sources & evidence

ORD record
ord-a4f01b70856f4343a138a9af23312551
Source dataset
uspto-grants-2012_05
Patent number
US08183275B2

Reaction notes

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