2,4-Dichloropyrimidine → HCID 57468808, compound

HRID 1927951Notes

Reaction equation

HRID 1927951 reaction equation
I[C:2]1[CH:7]=[C:6]([CH3:8])[CH:5]=[C:4]([C:9]2[CH:14]=[CH:13][C:12]([C:15]([F:18])([F:17])[F:16])=[CH:11][CH:10]=2)[N:3]=1.[Cl:19][C:20]1[N:25]=[C:24](Cl)[CH:23]=[CH:22][N:21]=1>C([Mg]Cl)(C)C.[Cl-].[Cl-].[Zn+2]>[Cl:19][C:20]1[N:25]=[C:24]([C:2]2[CH:7]=[C:6]([CH3:8])[CH:5]=[C:4]([C:9]3[CH:14]=[CH:13][C:12]([C:15]([F:18])([F:17])[F:16])=[CH:11][CH:10]=3)[N:3]=2)[CH:23]=[CH:22][N:21]=1

Participants

4

Reactant 2

HCID 775312,4-DichloropyrimidineHCID 574686822-Iodo-4-methyl-6-(4-trifluoromethyl-phenyl)pyridine

Product 1

HCID 57468808HCID 57468808, compound

Reagents, catalysts & solvents 1

HCID 178461731HCID 178461731, compoundCatalyst

Procedure

The title compound was prepared from 2-iodo-4-methyl-6-(4-trifluoromethyl-phenyl)-pyridine (example A.58) (2.55 g, 7.0 mmol), i-PrMgCl/ZnCl2 and commercially available 2,4-dichloropyrimidine (1.08 g, 7.21 mmol) according to the general procedure IVc protocol b. Obtained as a light brown solid (0.896 g, 37%). MS (ISP) 350.3 [(M+H)+] and 352 [(M+2+H)+].

Sources & evidence

ORD record
ord-ee01ee855c9649fbbf37e785ea3b660e
Source dataset
uspto-grants-2012_05
Patent number
US08183262B2

Reaction notes

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