Triphosgene → HCID 44218262, compound

HRID 1928730Notes

Reaction equation

[C:1](=[O:12])(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl.[N:13]1([CH2:19][CH2:20][NH2:21])[CH2:18][CH2:17][O:16][CH2:15][CH2:14]1.[C@H:22]1([NH:31][C:32]2[CH:41]=[CH:40][C:39]3[C:34](=[CH:35][CH:36]=[C:37]([NH2:42])[CH:38]=3)[N:33]=2)[C:30]2[C:25](=[CH:26][CH:27]=[CH:28][CH:29]=2)[CH2:24][CH2:23]1>>[C@H:22]1([NH:31][C:32]2[CH:41]=[CH:40][C:39]3[C:34](=[CH:35][CH:36]=[C:37]([NH:42][C:1]([NH:21][CH2:20][CH2:19][N:13]4[CH2:18][CH2:17][O:16][CH2:15][CH2:14]4)=[O:12])[CH:38]=3)[N:33]=2)[C:30]2[C:25](=[CH:26][CH:27]=[CH:28][CH:29]=2)[CH2:24][CH2:23]1

Participants

Reactant 3

HCID 94429Triphosgene

HCID 4082852-Morpholinoethylamine

HCID 57860958(R)-N2-Indan-1-yl-quinoline-2,6-diamine

Product 1

HCID 44218262HCID 44218262, compound

Procedure

The title compound was prepared in accordance with the general method 4 described in example 16 from bis(trichloromethyl) carbonate, 2-morpholin-4-yl-ethylamine and (R)—N2-indan-1-yl-quinoline-2,6-diamine; MS: m/e=432.6 (M+H+).

Sources & evidence

ORD record: ord-5a331d02b9734c2bbc9db7485d09470e
Source dataset: uspto-grants-2012_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08183380B2

Reaction notes

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