1-Isopropylpiperazine → HCID 44218425, compound

HRID 1928810Notes

Reaction equation

[C:1](=[O:12])(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl.[CH3:13][CH:14]([N:16]1[CH2:21][CH2:20][NH:19][CH2:18][CH2:17]1)[CH3:15].[C@H:22]1([NH:31][C:32]2[CH:41]=[CH:40][C:39]3[C:34](=[CH:35][CH:36]=[C:37]([NH2:42])[CH:38]=3)[N:33]=2)[C:30]2[C:25](=[CH:26][CH:27]=[CH:28][CH:29]=2)[CH2:24][CH2:23]1>>[C@H:22]1([NH:31][C:32]2[CH:41]=[CH:40][C:39]3[C:34](=[CH:35][CH:36]=[C:37]([NH:42][C:1]([N:19]4[CH2:20][CH2:21][N:16]([CH:14]([CH3:15])[CH3:13])[CH2:17][CH2:18]4)=[O:12])[CH:38]=3)[N:33]=2)[C:30]2[C:25](=[CH:26][CH:27]=[CH:28][CH:29]=2)[CH2:24][CH2:23]1

Participants

Reactant 3

HCID 780131-Isopropylpiperazine

HCID 94429Triphosgene

HCID 57860958(R)-N2-Indan-1-yl-quinoline-2,6-diamine

Product 1

HCID 44218425HCID 44218425, compound

Procedure

The title compound was prepared in accordance with the general method 4 described in example 16 from bis(trichloromethyl) carbonate (44 mg, 0.16 mmol), commercially available 1-(2-propyl)-piperazine (47 mg, 0.363 mmol) and (R)—N2-indan-1-yl-quinoline-2,6-diamine (100 mg, 0.363 mmol); obtained as a white solid (32 mg, 21%); MS: m/e=430.4 (M+H+).

Sources & evidence

ORD record: ord-c718996f71d44853a36430646164ea02
Source dataset: uspto-grants-2012_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08183380B2

Reaction notes

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