Hydroxyamine hydrochloride → HCID 86634185, compound

HRID 1928863Notes

Reaction equation

HRID 1928863 reaction equation
[CH3:1][O:2][CH2:3][CH2:4][O:5][C:6]1[C:11]2[C:12](=O)[CH2:13][O:14][C:10]=2[CH:9]=[CH:8][CH:7]=1.C([O-])(=O)C.[Na+].Cl.[NH2:22][OH:23]>C(O)C>[CH3:1][O:2][CH2:3][CH2:4][O:5][C:6]1[C:11]2[C:12](=[N:22][OH:23])[CH2:13][O:14][C:10]=2[CH:9]=[CH:8][CH:7]=1

Participants

5

Reactant 3

HCID 443297Hydroxyamine hydrochlorideHCID 517045Sodium AcetateHCID 57545176HCID 57545176, compound

Product 1

HCID 86634185HCID 86634185, compoundYield 72.2%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
23 °C

Procedure

A mixture of the above described 4-(2-methoxy-ethoxy)-benzofuran-3-one (1.9 g, 9 mmol), sodium acetate (1.5 g, 19 mmol) and hydroxylamine hydrochloride (1.3 g, 19 mmol) in ethanol (15 mL) was refluxed for 4 h. Cooled to 23° C., filtered the precipitate off, washed with water and ethanol and dried in high vacuum to give the title compound as a white solid (1.45 g, 71%); MS: m/e=224.1 (M+H−).

Workup

  1. additionA mixture of the
  2. temperaturewas refluxed for 4 h
  3. filtrationfiltered the precipitate off,
  4. washwashed with water and ethanol
  5. customdried in high vacuum

Sources & evidence

ORD record
ord-dcf053b85b6f4648b79f8f0413c51d4c
Source dataset
uspto-grants-2012_05
Patent number
US08183380B2

Reaction notes

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