4-Nitrophenyl chloroformate → HCID 68633190, compound

HRID 1928876Notes

Reaction equation

HRID 1928876 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[CH:5][CH:6]=[C:7]2[C:11]=1[CH:10]([NH:12][C:13]1[CH:22]=[CH:21][C:20]3[C:15](=[CH:16][CH:17]=[C:18]([NH2:23])[CH:19]=3)[N:14]=1)[CH2:9][CH2:8]2.Cl[C:25](OC1C=CC([N+]([O-])=O)=CC=1)=[O:26].[NH2:37][CH:38]1[CH2:43][CH2:42][N:41]([CH2:44][CH2:45][OH:46])[CH2:40][CH2:39]1>>[OH:46][CH2:45][CH2:44][N:41]1[CH2:42][CH2:43][CH:38]([NH:37][C:25]([NH:23][C:18]2[CH:19]=[C:20]3[C:15](=[CH:16][CH:17]=2)[N:14]=[C:13]([NH:12][CH:10]2[C:11]4[C:7](=[CH:6][CH:5]=[CH:4][C:3]=4[O:2][CH3:1])[CH2:8][CH2:9]2)[CH:22]=[CH:21]3)=[O:26])[CH2:39][CH2:40]1

Participants

4

Reactant 3

HCID 821294-Nitrophenyl chloroformateHCID 157334452-(4-Aminopiperidin-1-yl)ethan-1-olHCID 57860964Rac-n2-(7-methoxy-indan-1-yl)-quinoline-2,6-diamine

Product 1

HCID 68633190HCID 68633190, compound

Procedure

The title compound was prepared from rac-N2-(7-methoxy-indan-1-yl)-quinoline-2,6-diamine (Example 172) (200 mg, 0.655 mmol), 4-nitrophenyl chloroformate (132 mg, 0.655 mmol) and commercially available 4-amino-1-piperidine ethanol (94 mg, 0.655 mmol) in accordance with the general method 4 described in example 170 step C and was obtained as an off-white solid (160 mg, 26%); MS: m/e=476.2 (M+H+).

Sources & evidence

ORD record
ord-1ad8107e4ce24e8db3c6faddd340acbb
Source dataset
uspto-grants-2012_05
Patent number
US08183380B2

Reaction notes

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