反应详情

Piperidin-4-ol (5 g, 49.4 mmol) is dissolved in 200 ml of ethanol and anhydrous sodium carbonate (21 g, 197.6 mmol) is added. 2-Bromo-ethanol (6.9 ml, 98.8 mmol) is added dropwise and the reaction mixture is refluxed for 16 hours. After evaporation under reduced pressure the mixture is stirred with 200 ml of DCM and filtered. The clear filtrate is evaporated under reduced pressure and dried at high vacuum.

1. temperaturethe reaction mixture is refluxed for 16 hours
2. customAfter evaporation under reduced pressure the mixture
3. filtrationfiltered
4. customThe clear filtrate is evaporated under reduced pressure
5. customdried at high vacuum