反应详情

A solution of 1-benzyl-piperidin-4-ol (25 g, 130.7 mmol) and triethylamine (36.1 ml, 261.4 mmol) in 250 ml of THF is treated with 2,2-dimethyl-propionyl chloride (32.2 ml, 261.4 mmol). The suspension is heated under reflux over night. The solvent is evaporated, the residue taken up in DCM and washed with saturated sodium bicarbonate solution and brine. Drying and evaporation gave an orange oil.

1. temperatureThe suspension is heated
2. temperatureunder reflux over night
3. customThe solvent is evaporated
4. washwashed with saturated sodium bicarbonate solution and brine
5. customDrying
6. customevaporation
7. customgave an orange oil