Hydrochloric Acid → HCID 66864764, compound

HRID 1929276Notes

Reaction equation

HRID 1929276 reaction equation
F[C:2]1[C:3]([S:15]([CH3:18])(=[O:17])=[O:16])=[C:4]([CH:8]=[CH:9][C:10]=1[C:11]([F:14])([F:13])[F:12])[C:5]([OH:7])=[O:6].[CH3:19][NH2:20].Cl>>[CH3:19][NH:20][C:2]1[C:3]([S:15]([CH3:18])(=[O:17])=[O:16])=[C:4]([CH:8]=[CH:9][C:10]=1[C:11]([F:14])([F:13])[F:12])[C:5]([OH:7])=[O:6]

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 6329MethylamineHCID 66864563HCID 66864563, compound

Product 1

HCID 66864764HCID 66864764, compound

Procedure

2.40 g (8.4 mmol) of 3-fluoro-2-methylsulfonyl-4-trifluoromethylbenzoic acid were treated with 12.1 ml (168 mmol; 40 percent strength) of aqueous methylamine solution and the mixture was stirred for 4 h at RT. For work-up, the contents were poured into 6 N HCl, the mixture was subsequently cooled in an ice-bath. The precipitate was filtered off with suction. This gave 2.50 g of product in 95% purity.

Workup

  1. temperaturethe mixture was subsequently cooled in an ice-bath
  2. filtrationThe precipitate was filtered off with suction

Sources & evidence

ORD record
ord-cf7db624ff0b48139761ca5bd4733f96
Source dataset
uspto-grants-2012_05
Patent number
US08188009B2

Reaction notes

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