Hydrochloric Acid → (R)-5-(5-Amino-2-fluoro-phenyl)-5-methyl-morpholine-3-thione

HRID 1929479Notes

Reaction equation

HRID 1929479 reaction equation
C(=[N:14][C:15]1[CH:16]=[CH:17][C:18]([F:29])=[C:19]([C@@:21]2([CH3:28])[NH:26][C:25](=[S:27])[CH2:24][O:23][CH2:22]2)[CH:20]=1)(C1C=CC=CC=1)C1C=CC=CC=1.Cl>>[NH2:14][C:15]1[CH:16]=[CH:17][C:18]([F:29])=[C:19]([C@@:21]2([CH3:28])[NH:26][C:25](=[S:27])[CH2:24][O:23][CH2:22]2)[CH:20]=1

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 86651220(R)-5-[5-(Benzhydrylidene-amino)-2-fluoro-phenyl]-5-methyl-morpholine-3-thione

Product 1

HCID 58155253(R)-5-(5-Amino-2-fluoro-phenyl)-5-methyl-morpholine-3-thione

Procedure

In a manner analogous to the preparation of Building block E the hydrolysis of (R)-5-[5-(benzhydrylidene-amino)-2-fluoro-phenyl]-5-methyl-morpholine-3-thione with hydrochloric acid yielded the title compound as a light brown foam. Mass (calculated) C11H13FN2OS [240.301]; (found) [M+H]+=241.

Workup

  1. customIn a manner analogous to the preparation of Building block E

Sources & evidence

ORD record
ord-2e887b1b822049b1a95b4981e673903e
Source dataset
uspto-grants-2012_05
Patent number
US08188079B2

Reaction notes

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