Malonic Acid → HCID 53395407, compound

HRID 1929608Notes

Reaction equation

HRID 1929608 reaction equation
[CH3:1][C:2]1[CH:9]=[C:8]([CH3:10])[CH:7]=[CH:6][C:3]=1[CH:4]=O.C(O)(=O)[CH2:12][C:13]([OH:15])=[O:14]>>[CH3:1][C:2]1[CH:9]=[C:8]([CH3:10])[CH:7]=[CH:6][C:3]=1[CH:4]=[CH:12][C:13]([OH:15])=[O:14]

Participants

3

Reactant 2

HCID 867Malonic AcidHCID 618142,4-Dimethylbenzaldehyde

Product 1

HCID 53395407HCID 53395407, compound

Procedure

According to the previously described general procedure (GP1), Knoevenagel condensation (75° C.; 3h30) between 2,4-dimethyl-benzaldehyde (10.000 g; 74.528 mmol) and malonic acid (14.735 g; 141.607 mmol) gave the product 3-(2,4-dimethyl-phenyl)-acrylic acid as a colorless solid (9.720 g; 74%). LC-MS: tR=0.86 min; [M+H]+: no ionisation.

Sources & evidence

ORD record
ord-3a15e183d053496eba6c1e98fa8c4e6b
Source dataset
uspto-grants-2012_05
Patent number
US08188082B2

Reaction notes

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