Potassium Carbonate → HCID 28829557, compound

HRID 1929627Notes

Reaction equation

HRID 1929627 reaction equation
[F:1][C:2]([F:11])([F:10])[C:3]1[CH:8]=[CH:7][C:6]([OH:9])=[CH:5][CH:4]=1.C(=O)([O-])[O-].[K+].[K+].Br[CH2:19][C:20]([O:22][CH3:23])=[O:21]>CC(C)=O>[CH3:23][O:22][C:20](=[O:21])[CH2:19][O:9][C:6]1[CH:5]=[CH:4][C:3]([C:2]([F:10])([F:11])[F:1])=[CH:8][CH:7]=1

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 60984Methyl bromoacetateHCID 678744-(Trifluoromethyl)phenol

Product 1

HCID 28829557HCID 28829557, compound

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

A mixture of 4-trifluoromethyl-phenol (10.000 g; 61.687 mmol), potassium carbonate (9.377 g; 67.856 mmol), and methyl bromoacetate (5.67 ml; 61.687 mmol) in acetone (250 ml) was heated at reflux for 1 h30. Filtration, concentration to dryness under reduced pressure, and purification by FC (DCM) afforded (4-trifluoromethyl-phenoxy)-acetic acid methyl ester as a colorless oil (14.100 g; 98%). LC-MS: tR=0.95 min.; [M+H]+: no ionisation.

Workup

  1. temperaturewas heated
  2. temperatureat reflux for 1 h30
  3. filtrationFiltration, concentration to dryness
  4. customunder reduced pressure, and purification by FC (DCM)

Sources & evidence

ORD record
ord-7c8b12a40d6542fd94e3e4a50aba03b6
Source dataset
uspto-grants-2012_05
Patent number
US08188082B2

Reaction notes

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