Methylamine → HCID 69038476, compound

HRID 1930319Notes

Reaction equation

HRID 1930319 reaction equation
[NH2:1][C:2]1[CH:3]=[CH:4][C:5]([Cl:22])=[C:6]([C:8]2[C:19](=[O:20])[N:18]([CH3:21])[C:11]3[N:12]=[C:13](SC)[N:14]=[CH:15][C:10]=3[CH:9]=2)[CH:7]=1.C1C=C(Cl)C=C(C(OO)=O)C=1.[CH3:34][NH2:35]>>[NH2:1][C:2]1[CH:3]=[CH:4][C:5]([Cl:22])=[C:6]([C:8]2[C:19](=[O:20])[N:18]([CH3:21])[C:11]3[N:12]=[C:13]([NH:35][CH3:34])[N:14]=[CH:15][C:10]=3[CH:9]=2)[CH:7]=1

Participants

4

Reactant 3

HCID 6329MethylamineHCID 70297m-Chloroperbenzoic acidHCID 69036754HCID 69036754, compound

Product 1

HCID 69038476HCID 69038476, compoundYield 80%

Procedure

6-(5-amino-2-chlorophenyl)-8-methyl-2-(methylthio)pyrido[2,3-d]pyrimidin-7(8H)-one (0.500 g, 1.5 mmol), mCPBA (0.481 g, 1.953 mmol) and methylamine (0.76 mL. 2.0 M in THF, 1.52 mmol) were combined by analogy to Example A1 to provide 6-(5-amino-2-chlorophenyl)-8-methyl-2-(methylamino)pyrido[2,3-d]pyrimidin-7(8H)-one (0.378 g, 80% yield). MS (ESI) m/z: 316.0 (M+H+).

Sources & evidence

ORD record
ord-cc5f2820f0a742e19505834900e1d0b2
Source dataset
uspto-grants-2012_05
Patent number
US08188113B2

Reaction notes

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