Lithium Hydroxide → 1-isopropyl-3-(thiophen-2-yl)-1H-pyrazole-5-carboxylic acid

HRID 1930338ノート

反応式

HRID 1930338 の反応式
[CH:1]([N:4]1[C:8]([C:9]([O:11]CC)=[O:10])=[CH:7][C:6]([C:14]2[S:15][CH:16]=[CH:17][CH:18]=2)=[N:5]1)([CH3:3])[CH3:2].[Li+].[OH-]>C1COCC1>[CH:1]([N:4]1[C:8]([C:9]([OH:11])=[O:10])=[CH:7][C:6]([C:14]2[S:15][CH:16]=[CH:17][CH:18]=2)=[N:5]1)([CH3:3])[CH3:2]

参加物

4

反応物 2

HCID 3939Lithium HydroxideHCID 59826475ethyl 1-isopropyl-3-(thiophen-2-yl)-1H-pyrazole-5-carboxylate

生成物 1

HCID 690359331-isopropyl-3-(thiophen-2-yl)-1H-pyrazole-5-carboxylic acid収率 88.5%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

To a solution of ethyl 1-isopropyl-3-(thiophen-2-yl)-1H-pyrazole-5-carboxylate (0.88 g, 3.3 mmol) in THF (10 mL) was added aq. LiOH solution (0.42 g, 10 mmol, 5 mL) and the mixture was stirred for 16 h at RT. Solvents were removed and the thick liquid was diluted with water (5 mL) and acidified with 3M HCl solution to pH 4-5. The product precipitated and was filtered, washed with water and dried to afford 1-isopropyl-3-(thiophen-2-yl)-1H-pyrazole-5-carboxylic acid as a white solid (0.69 g, 88% yield).

後処理

  1. customSolvents were removed
  2. additionthe thick liquid was diluted with water (5 mL)
  3. customThe product precipitated
  4. filtrationwas filtered
  5. washwashed with water
  6. customdried

出典と根拠

ORDレコード
ord-fa757c7508754405892e4d59cabf9e31
出典データセット
uspto-grants-2012_05
特許番号
US08188113B2

反応ノート

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