反应详情

3-Methoxy-4-(4-methyl-1H-imidazol-1-yl)aniline hydrochloride (3 g, 12.52 mmol), cyanamide (0.684 g, 16.27 mmol) and hydrochloric acid (1.564 mL, 18.77 mmol) in ethanol (20 mL) were heated to reflux o.n. The reaction mixture was concentrated under reduced pressure before the resulting mixture was poured on a solution of potassium carbonate (1.730 g, 12.52 mmol) in water (60 mL) and left in refrigerator o.n. The formed carbonate-salt was filtered off, and dried in vacuum oven o.n. The solid was washed with several portions of DCM, dried and used as such in next step.

1. temperatureto reflux o.n
2. concentrationThe reaction mixture was concentrated under reduced pressure before the resulting mixture
3. waitleft in refrigerator o.n
4. filtrationThe formed carbonate-salt was filtered off
5. customdried in vacuum oven o.n
6. washThe solid was washed with several portions of DCM
7. customdried