反应详情

2-((2-(4-(Oxazol-5-yl)phenylamino)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-yl)(phenyl)amino)ethanol (50 mg, 0.12 mmol, Example 1) was dissolved in dichloromethane (5 mL) and methanol (1 mL). Triethylamine (0.016 mL, 0.12 mmol) was added followed by dimethylcarbamyl chloride (10.72 μL, 0.12 mmol). The reaction mixture was stirred at room temperature for 2 h. The solvent was evaporated under reduced pressure, the crude dissolved in few drops of dimethylformamide and acetonitrile, filtered and purified by HPLC yielding 4-((2-hydroxyethyl)(phenyl)amino)-N,N-dimethyl-2-(4-(oxazol-5-yl)phenylamino)-7,8-dihydropyrido[4,3-d]pyrimidine-6(5H)-carboxamide (19.0 mg, 33%).

1. customThe solvent was evaporated under reduced pressure
2. dissolutionthe crude dissolved in few drops of dimethylformamide and acetonitrile
3. filtrationfiltered
4. custompurified by HPLC