反应详情

温度

110 °C

tert-Butyl 2-(4-bromophenylamino)-4-hydroxy-7,8-dihydropyrido[4,3-d]pyrimidine-6(5H)-carboxylate (1.4 g, 3.32 mmol), 1-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H pyrazole (0.691 g, 3.32 mmol), dichloro[1,1′-bis(di-tert-butylphosphino)ferrocene]palladium (II), Pd-118 (0.108 g, 0.17 mmol) and potassium carbonate (1.837 g, 13.29 mmol) in DMF (5 mL), water (2.5 mL) and ethanol (0.833 mL) were charged in a thick wall glass, which was sealed and heated at 110° C. for 20 minutes. The raction mixture was allowed to cool down, the crude was filtered through celite and the filtercake washed with ethanol. The solvent was evaporated under reduced pressure. The crude was used in the next step without further purification. MS (ESI) (M+1) m/z 423

1. customwas sealed
2. temperatureto cool down
3. filtrationthe crude was filtered through celite
4. washthe filtercake washed with ethanol
5. customThe solvent was evaporated under reduced pressure
6. customThe crude was used in the next step without further purification