Phenylacetyl chloride → 3-(2-phenylacetyl)dihydro-2H-pyran-4(3H)-one

HRID 1930598Notes

Reaction equation

[O:1]1[CH2:6][CH2:5][C:4](=[O:7])[CH2:3][CH2:2]1.[C:8]1([CH2:14][C:15](Cl)=[O:16])[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1>>[C:8]1([CH2:14][C:15]([CH:3]2[C:4](=[O:7])[CH2:5][CH2:6][O:1][CH2:2]2)=[O:16])[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1

Participants

Reactant 2

HCID 7679Phenylacetyl chloride

HCID 121599Tetrahydro-4H-pyran-4-one

Product 1

HCID 593337793-(2-phenylacetyl)dihydro-2H-pyran-4(3H)-oneYield 49.4%

Procedure

3-(2-Phenylacetyl)dihydro-2H-pyran-4(3H)-one (0.538 g, 49.4%) was synthesised from tetrahydro-4H-pyran-4-one (0.923 mL, 9.99 mmol) and phenylacetyl chloride (0.660 mL, 4.99 mmol) by the general procedure for the preparation of ketones.

Sources & evidence

ORD record: ord-9a9d2f0a791a484bb679de8fd6c92e90
Source dataset: uspto-grants-2012_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08188101B2

Reaction notes

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