Tetrahydro-4H-pyran-4-one → 3-(2-Methoxy-2-phenylacetyl)dihydro-2H-pyran-4(3H)-one

HRID 1930630Notes

Reaction equation

HRID 1930630 reaction equation
[CH3:1][O:2][CH:3]([C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1)[C:4](Cl)=[O:5].[O:13]1[CH2:18][CH2:17][C:16](=[O:19])[CH2:15][CH2:14]1>>[CH3:1][O:2][CH:3]([C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1)[C:4]([CH:15]1[C:16](=[O:19])[CH2:17][CH2:18][O:13][CH2:14]1)=[O:5]

Participants

3

Reactant 2

HCID 121599Tetrahydro-4H-pyran-4-oneHCID 126359552-Methoxy-2-phenylacetyl chloride

Product 1

HCID 593336923-(2-Methoxy-2-phenylacetyl)dihydro-2H-pyran-4(3H)-oneYield 14.5%

Procedure

3-(2-Methoxy-2-phenylacetyl)dihydro-2H-pyran-4(3H)-one (54 mg, 14.5%) was synthesised from 2-methoxy-2-phenylacetyl chloride and dihydro-2H-pyran-4(3H)-one according to the general procedure for the preparation of diketones. MS (ES−) m/z 247.1 (M−H)−

Sources & evidence

ORD record
ord-5f077bf3e1df43ba99accda24ebe9d25
Source dataset
uspto-grants-2012_05
Patent number
US08188101B2

Reaction notes

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