Hydrochloric Acid → HCID 59333775, compound

HRID 1930670Notes

Reaction equation

HRID 1930670 reaction equation
[O:1]1[C:5]([C:6]2[CH:11]=[CH:10][C:9]([NH:12][C:13]3[N:14]=[C:15]([NH:30][CH2:31][C@@H:32]4[CH2:36][CH2:35][CH2:34][O:33]4)[C:16]4[CH2:22][N:21](C(OC(C)(C)C)=O)[CH2:20][CH2:19][C:17]=4[N:18]=3)=[CH:8][CH:7]=2)=[CH:4][N:3]=[CH:2]1.Cl>CO>[O:1]1[C:5]([C:6]2[CH:7]=[CH:8][C:9]([NH:12][C:13]3[N:14]=[C:15]([NH:30][CH2:31][C@@H:32]4[CH2:36][CH2:35][CH2:34][O:33]4)[C:16]4[CH2:22][NH:21][CH2:20][CH2:19][C:17]=4[N:18]=3)=[CH:10][CH:11]=2)=[CH:4][N:3]=[CH:2]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 59333740HCID 59333740, compound

Product 1

HCID 59333775HCID 59333775, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
75 °C

Procedure

(S)-tert-Butyl 2-(4-(oxazol-5-yl)phenylamino)-4-((tetrahydrofuran-2-yl)methylamino)-7,8-dihydropyrido[4,3-d]pyrimidine-6(5H)-carboxylate was dissolved in methanol (3 mL). Hydrochloric acid was added and the reaction mixture was stirred at 75° C. for 1 h. The solvent was evaporated under reduced pressure and the crude was used as such in the next step. MS (ES+) m/z 393.2 (M+H)+

Workup

  1. customThe solvent was evaporated under reduced pressure

Sources & evidence

ORD record
ord-94ac3f8298524795ba7c89948d7d2e6e
Source dataset
uspto-grants-2012_05
Patent number
US08188101B2

Reaction notes

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