Tetrahydro-4H-pyran-4-one → 3-(2-(3,5-dimethyl-1H-pyrazol-1-yl)propanoyl)dihydro-2H-pyran-4(3H)-one

HRID 1930707Notes

Reaction equation

HRID 1930707 reaction equation
[CH3:1][C:2]1[CH:6]=[C:5]([CH3:7])[N:4]([CH:8]([CH3:12])[C:9](Cl)=[O:10])[N:3]=1.[O:13]1[CH2:18][CH2:17][C:16](=[O:19])[CH2:15][CH2:14]1>>[CH3:1][C:2]1[CH:6]=[C:5]([CH3:7])[N:4]([CH:8]([CH3:12])[C:9]([CH:15]2[C:16](=[O:19])[CH2:17][CH2:18][O:13][CH2:14]2)=[O:10])[N:3]=1

Participants

3

Reactant 2

HCID 121599Tetrahydro-4H-pyran-4-oneHCID 59333819HCID 59333819, compound

Product 1

HCID 593337123-(2-(3,5-dimethyl-1H-pyrazol-1-yl)propanoyl)dihydro-2H-pyran-4(3H)-one

Procedure

3-(2-(3,5-Dimethyl-1H-pyrazol-1-yl)propanoyl)dihydro-2H-pyran-4 (3H)-one was synthesised from 2-(3,5-dimethyl-1H-pyrazol-1-yl)propanoyl chloride (0.5 g, 2.97 mmol) and tetrahydro-4H-pyran-4-one (0.549 mL, 5.95 mmol) by the general procedure for the preparation of diketones. MS (ES+) m/z 251.1 (M+H)+

Sources & evidence

ORD record
ord-ecb3aaf9a55443da8276bd1da3f38d8b
Source dataset
uspto-grants-2012_05
Patent number
US08188101B2

Reaction notes

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