Tetrahydro-4H-pyran-4-one → 3-(2-(Cyclopentyloxy)acetyl)dihydro-2H-pyran-4(3H)-one

HRID 1930718Notes

Reaction equation

HRID 1930718 reaction equation
[O:1]1[CH2:6][CH2:5][C:4](=[O:7])[CH2:3][CH2:2]1.[CH:8]1([O:13][CH2:14][C:15](Cl)=[O:16])[CH2:12][CH2:11][CH2:10][CH2:9]1>>[CH:8]1([O:13][CH2:14][C:15]([CH:3]2[C:4](=[O:7])[CH2:5][CH2:6][O:1][CH2:2]2)=[O:16])[CH2:12][CH2:11][CH2:10][CH2:9]1

Participants

3

Reactant 2

HCID 121599Tetrahydro-4H-pyran-4-oneHCID 866419172-(Cyclopentyloxy)acetyl chloride

Product 1

HCID 593337153-(2-(Cyclopentyloxy)acetyl)dihydro-2H-pyran-4(3H)-oneYield 37.5%

Procedure

3-(2-(cyclopentyloxy)acetyl)dihydro-2H-pyran-4(3H)-one (280 mg, 21.5%) was synthesised from dihydro-2H-pyran-4(3H)-one (0.462 ml, 5.00 mmol) and (2-(cyclopentyloxy)acetyl chloride (3.3 mmol) by the general procedure for the preparation of diketones.

Sources & evidence

ORD record
ord-a05ef98cc5014ca9b575f0b3ef12da94
Source dataset
uspto-grants-2012_05
Patent number
US08188101B2

Reaction notes

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