tert-Butyl 5-iodoisoindoline-2-carboxylate → 5-Isopropoxy-1,3-dihydro-isoindole-2-carboxylic acid tert-butyl ester

HRID 1930861Notes

Reaction equation

HRID 1930861 reaction equation
[C:1]([O:5][C:6]([N:8]1[CH2:16][C:15]2[C:10](=[CH:11][CH:12]=[C:13](I)[CH:14]=2)[CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2]>CC(O)C>[C:1]([O:5][C:6]([N:8]1[CH2:16][C:15]2[C:10](=[CH:11][CH:12]=[C:13]([O:5][CH:1]([CH3:3])[CH3:2])[CH:14]=2)[CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2]

Participants

3

Reactant 1

HCID 57753580tert-Butyl 5-iodoisoindoline-2-carboxylate

Product 1

HCID 577533995-Isopropoxy-1,3-dihydro-isoindole-2-carboxylic acid tert-butyl ester

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

Prepared in analogy to Example A6(a) from 5-iodo-1,3-dihydro-isoindole-2-carboxylic acid tert-butyl ester (Example A38(b)) and 2-propanol. White solid. MS (m/e): 222.1 ([M+H-Me2C═CH2]+, 100%).

Sources & evidence

ORD record
ord-ab8141574a814318a3560edeb15df78e
Source dataset
uspto-grants-2012_05
Patent number
US08188139B2

Reaction notes

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