Hydrochloric Acid → 5-Morpholin-4-yl-6-trifluoromethyl-2,3-dihydro-1H-isoindole hydrochloride

HRID 1930874Notes

Reaction equation

HRID 1930874 reaction equation
C(OC([N:8]1[CH2:16][C:15]2[C:10](=[CH:11][C:12]([C:23]([F:26])([F:25])[F:24])=[C:13]([N:17]3[CH2:22][CH2:21][O:20][CH2:19][CH2:18]3)[CH:14]=2)[CH2:9]1)=O)(C)(C)C.[ClH:27]>>[ClH:27].[N:17]1([C:13]2[CH:14]=[C:15]3[C:10](=[CH:11][C:12]=2[C:23]([F:26])([F:24])[F:25])[CH2:9][NH:8][CH2:16]3)[CH2:22][CH2:21][O:20][CH2:19][CH2:18]1

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 577535575-Morpholin-4-yl-6-trifluoromethyl-1,3-dihydro-isoindole-2-carboxylic acid tert-butyl ester

Product 1

HCID 688225215-Morpholin-4-yl-6-trifluoromethyl-2,3-dihydro-1H-isoindole hydrochloride

Procedure

Prepared in analogy to Example A3(e) from 5-morpholin-4-yl-6-trifluoromethyl-1,3-dihydro-isoindole-2-carboxylic acid tert-butyl ester and hydrochloric acid. Off-white solid. MS (m/e): 273.0 ([M+H]+, 100%).

Sources & evidence

ORD record
ord-19e7bb2753c4462db344c3547f6c3211
Source dataset
uspto-grants-2012_05
Patent number
US08188139B2

Reaction notes

Loading…