Hydrochloric Acid → Rac-5-(tetrahydro-pyran-3-yl)-2,3-dihydro-1h-isoindole

HRID 1930935Notes

Reaction equation

HRID 1930935 reaction equation
C(OC([N:8]1[CH2:16][C:15]2[C:10](=[CH:11][CH:12]=[C:13]([CH:17]3[CH2:22][CH2:21][CH2:20][O:19][CH2:18]3)[CH:14]=2)[CH2:9]1)=O)(C)(C)C.Cl>>[O:19]1[CH2:20][CH2:21][CH2:22][CH:17]([C:13]2[CH:14]=[C:15]3[C:10](=[CH:11][CH:12]=2)[CH2:9][NH:8][CH2:16]3)[CH2:18]1

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 57753408Rac-5-(tetrahydro-pyran-3-yl)-1,3-dihydro-isoindole-2-carboxylic acid tert-butyl ester

Product 1

HCID 57753682Rac-5-(tetrahydro-pyran-3-yl)-2,3-dihydro-1h-isoindole

Procedure

Prepared in analogy to Example A3(e) from rac-5-(tetrahydro-pyran-3-yl)-1,3-dihydro-isoindole-2-carboxylic acid tert-butyl ester and hydrochloric acid. Brown oil. MS (m/e): 204.3 ([M+H]+, 100%).

Sources & evidence

ORD record
ord-f905ebd94e074b198f179f27ea9fdcaf
Source dataset
uspto-grants-2012_05
Patent number
US08188139B2

Reaction notes

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