Trifluoroacetic acid → HCID 66646394, compound

HRID 1931057Notes

Reaction equation

HRID 1931057 reaction equation
C(OC(=O)/C=C/C1([S:14]([C:17]2[CH:22]=[CH:21][C:20]([CH2:23][N:24]([CH2:36][CH2:37][O:38][Si:39]([C:42]([CH3:45])([CH3:44])[CH3:43])([CH3:41])[CH3:40])[CH2:25][CH2:26][C:27]3[C:35]4[C:30](=[CH:31][CH:32]=[CH:33][CH:34]=4)[NH:29][CH:28]=3)=[CH:19][CH:18]=2)(=[O:16])=[O:15])C=CNC1)(C)(C)C.[C:47]([OH:53])([C:49](F)(F)F)=[O:48]>ClCCl>[C:42]([Si:39]([CH3:40])([CH3:41])[O:38][CH2:37][CH2:36][N:24]([CH2:23][C:20]1[CH:19]=[CH:18][C:17]([S:14]([N:29]2[CH:30]=[CH:35][C:27](/[CH:26]=[CH:49]/[C:47]([OH:53])=[O:48])=[CH:28]2)(=[O:16])=[O:15])=[CH:22][CH:21]=1)[CH2:25][CH2:26][C:27]1[C:35]2[C:30](=[CH:31][CH:32]=[CH:33][CH:34]=2)[NH:29][CH:28]=1)([CH3:44])([CH3:43])[CH3:45]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 66646170HCID 66646170, compound2×

Product 1

HCID 66646394HCID 66646394, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

(E)-3-{3-[4-({[2-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-[2-(1H-indol-3-yl)-ethyl]-amino}methyl)-benzenesulfonyl]-1H-pyrrol-3-yl}-acrylic acid tert-butyl ester (compound D5) is dissolved in dichloromethane (50 ml). Then it is added TFA and the mixture is stirred for 26 hours. After evaporation, the residue is washed with toluene.

Workup

  1. customAfter evaporation
  2. washthe residue is washed with toluene

Sources & evidence

ORD record
ord-8d39f4164aa941778ea516d869b8d796
Source dataset
uspto-grants-2012_05
Patent number
US08188138B2

Reaction notes

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