Pyrrolidine → 2-[4-(4-Fluoro-phenyl)-thiazol-2-ylamino]-1-(pyrrolidin-1-yl)-ethanone trifluoroacetic acid salt

HRID 1931425Notes

Reaction equation

HRID 1931425 reaction equation
[F:1][C:2]([F:7])([F:6])[C:3]([OH:5])=[O:4].[F:8][C:9]1[CH:14]=[CH:13][C:12]([C:15]2[N:16]=[C:17]([NH:20][CH2:21][C:22]([OH:24])=O)[S:18][CH:19]=2)=[CH:11][CH:10]=1.[NH:25]1[CH2:29][CH2:28][CH2:27][CH2:26]1>>[F:1][C:2]([F:7])([F:6])[C:3]([OH:5])=[O:4].[F:8][C:9]1[CH:10]=[CH:11][C:12]([C:15]2[N:16]=[C:17]([NH:20][CH2:21][C:22]([N:25]3[CH2:29][CH2:28][CH2:27][CH2:26]3)=[O:24])[S:18][CH:19]=2)=[CH:13][CH:14]=1

Participants

3

Reactant 2

HCID 31268PyrrolidineHCID 44184931[4-(4-Fluoro-phenyl)-thiazol-2-ylamino]-acetic acid trifluoroacetic acid salt

Product 1

HCID 441850182-[4-(4-Fluoro-phenyl)-thiazol-2-ylamino]-1-(pyrrolidin-1-yl)-ethanone trifluoroacetic acid salt

Procedure

The title compound was prepared analogously as described in Example 30(d) from 100 mg (0.27 mmol) of [4-(4-fluoro-phenyl)-thiazol-2-ylamino]-acetic acid trifluoroacetic acid salt and 38.8 mg (0.54 mmol) of pyrrolidine. Yield: 17 mg.

Sources & evidence

ORD record
ord-9174c33fdcdc4afea4b3007f8be6b3f9
Source dataset
uspto-grants-2012_05
Patent number
US08188291B2

Reaction notes

Loading…