Piperidine → 2-[6-(2-Fluoro-phenyl)-pyridin-3-yloxy]-1-(piperidin-1-yl)-ethanone trifluoroacetic acid salt

HRID 1931437Notes

Reaction equation

HRID 1931437 reaction equation
[F:1][C:2]([F:7])([F:6])[C:3]([OH:5])=[O:4].[F:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1[C:15]1[N:20]=[CH:19][C:18]([O:21][CH2:22][C:23]([OH:25])=O)=[CH:17][CH:16]=1.[NH:26]1[CH2:31][CH2:30][CH2:29][CH2:28][CH2:27]1>>[F:1][C:2]([F:7])([F:6])[C:3]([OH:5])=[O:4].[F:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1[C:15]1[N:20]=[CH:19][C:18]([O:21][CH2:22][C:23]([N:26]2[CH2:31][CH2:30][CH2:29][CH2:28][CH2:27]2)=[O:25])=[CH:17][CH:16]=1

Participants

3

Reactant 2

HCID 8082PiperidineHCID 68540719[6-(2-Fluoro-phenyl)-pyridin-3-yloxy]-acetic acid trifluoroacetic acid salt

Product 1

HCID 685366482-[6-(2-Fluoro-phenyl)-pyridin-3-yloxy]-1-(piperidin-1-yl)-ethanone trifluoroacetic acid salt

Procedure

The title compound was prepared analogously as described in Example 30(d) from 100 mg (0.277 mmol) of [6-(2-fluoro-phenyl)-pyridin-3-yloxy]-acetic acid trifluoroacetic acid salt and 47.1 mg (0.554 mmol) of piperidine. Yield: 72 mg.

Sources & evidence

ORD record
ord-83928d1027ac4ac186c1cfc9e4c0e2d4
Source dataset
uspto-grants-2012_05
Patent number
US08188291B2

Reaction notes

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