Octadecylamine → HCID 16103189, compound

HRID 1931787Notes

Reaction equation

HRID 1931787 reaction equation
[CH2:1]([NH2:19])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH3:18].[S:20](N)([NH2:23])(=[O:22])=[O:21]>C1COCC1>[CH2:1]([NH:19][S:20]([NH2:23])(=[O:22])=[O:21])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH3:18]

Participants

4

Reactant 2

HCID 15793OctadecylamineHCID 82267Sulfamide

Product 1

HCID 16103189HCID 16103189, compoundYield 18%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

0.270 g, (1.0 mmol) of N-octadecylamine and 0.100 g (1.0 mmol) of sulfamide in 50 ml of THF (50 mL) are stirred and refluxed for 51 h. The solvent is evaporated and the crude is purified in a chromatography column, using CH2Cl2:MeOH/NH3 9:1 as eluyent. 0.06 g of white solid are obtained. Yield 18%; mp=105-107° C.;

Workup

  1. temperaturerefluxed for 51 h
  2. customThe solvent is evaporated
  3. customthe crude is purified in a chromatography column

Sources & evidence

ORD record
ord-3703a0666b52499792528e575d98e3f9
Source dataset
uspto-grants-2012_05
Patent number
US08188312B2

Reaction notes

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