Hydrochloric Acid → HCID 67143039, compound

HRID 1932393Notes

Reaction equation

HRID 1932393 reaction equation
[CH2:1]([N:8]1[C:12]2=[C:13]([N:19]3[CH2:28][CH2:27][C:26]4[C:21](=[CH:22][CH:23]=[CH:24][CH:25]=4)[CH2:20]3)[N:14]=[C:15]([CH2:17][OH:18])[CH:16]=[C:11]2[C:10]([CH3:29])=[C:9]1[CH3:30])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[ClH:31]>C(OCC)(=O)C>[ClH:31].[CH2:1]([N:8]1[C:12]2=[C:13]([N:19]3[CH2:28][CH2:27][C:26]4[C:21](=[CH:22][CH:23]=[CH:24][CH:25]=4)[CH2:20]3)[N:14]=[C:15]([CH2:17][OH:18])[CH:16]=[C:11]2[C:10]([CH3:29])=[C:9]1[CH3:30])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 67143040HCID 67143040, compound

Product 1

HCID 67143039HCID 67143039, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

A solution of [1-benzyl-7-(3,4-dihydro-1H-isoquinolin-2-yl)-2,3-dimethyl-1H-pyrrolo[2,3-c]pyridin-5-yl]-methanol prepared in Step 2 in ethyl acetate was saturated with hydrochloric acid gas and then filtered to give 10.2 mg of the titled compound as a white solid.

Workup

  1. filtrationfiltered

Sources & evidence

ORD record
ord-5a9b478b73064ab4b3a47c8c213fbf05
Source dataset
uspto-grants-2012_05
Patent number
US08188114B2

Reaction notes

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