Hydrochloric Acid → HCID 67142100, compound

HRID 1932402Notes

Reaction equation

HRID 1932402 reaction equation
[CH2:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH2:4][CH2:3][N:2]1[C:11]1[N:12]=[C:13]([CH2:30][NH:31][CH2:32][C:33]2[CH:38]=[CH:37][CH:36]=[C:35]([Cl:39])[CH:34]=2)[CH:14]=[C:15]2[C:19]([CH3:20])=[C:18]([CH3:21])[N:17]([CH2:22][C:23]3[CH:28]=[CH:27][CH:26]=[C:25]([F:29])[CH:24]=3)[C:16]=12.Cl>C(OCC)(=O)C>[ClH:39].[CH2:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH2:4][CH2:3][N:2]1[C:11]1[N:12]=[C:13]([CH2:30][NH:31][CH2:32][C:33]2[CH:38]=[CH:37][CH:36]=[C:35]([Cl:39])[CH:34]=2)[CH:14]=[C:15]2[C:19]([CH3:20])=[C:18]([CH3:21])[N:17]([CH2:22][C:23]3[CH:28]=[CH:27][CH:26]=[C:25]([F:29])[CH:24]=3)[C:16]=12

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 67142101HCID 67142101, compound

Product 1

HCID 67142100HCID 67142100, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

A solution of (3-chlorobenzyl)-[7-(3,4-dihydro-1H-isoquinolin-2-yl)-1-(3-fluorobenzyl)-2,3-dimethyl-1H-pyrrolo[2,3-c]pyridin-5-ylmethyl]-amine prepared in Step 1 in ethyl acetate was saturated with hydrochloric acid gas and then filtered to give 15.2 mg of the titled compound as a white solid.

Workup

  1. filtrationfiltered

Sources & evidence

ORD record
ord-e9daa7faba474b2c9c1e8000f4236738
Source dataset
uspto-grants-2012_05
Patent number
US08188114B2

Reaction notes

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