Hydrochloric Acid → HCID 67142307, compound

HRID 1932403Notes

Reaction equation

HRID 1932403 reaction equation
[CH3:1][C:2]1[NH:28][C:5]2=[C:6]([N:18]3[CH2:27][CH2:26][C:25]4[C:20](=[CH:21][CH:22]=[CH:23][CH:24]=4)[CH2:19]3)[N:7]=[C:8]([CH2:10][N:11]3[CH2:16][CH2:15][N:14]([CH3:17])[CH2:13][CH2:12]3)[CH:9]=[C:4]2[C:3]=1[CH3:29].[ClH:30]>C(OCC)(=O)C>[ClH:30].[CH3:1][C:2]1[NH:28][C:5]2=[C:6]([N:18]3[CH2:27][CH2:26][C:25]4[C:20](=[CH:21][CH:22]=[CH:23][CH:24]=4)[CH2:19]3)[N:7]=[C:8]([CH2:10][N:11]3[CH2:12][CH2:13][N:14]([CH3:17])[CH2:15][CH2:16]3)[CH:9]=[C:4]2[C:3]=1[CH3:29]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 67142308HCID 67142308, compound

Product 1

HCID 67142307HCID 67142307, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

A solution of 2-[2,3-dimethyl-5-(4-methylpiperazin-1-ylmethyl)-1H-pyrrolo[2,3-c]pyridin-7-yl]-1,2,3,4-tetrahydroisoquinoline prepared in Step 1 in ethyl acetate was saturated with hydrochloric acid gas and filtered. The resulting solid was dried under reduced pressure to give 3.4 mg of the titled compound as a white solid.

Workup

  1. filtrationfiltered
  2. customThe resulting solid was dried under reduced pressure

Sources & evidence

ORD record
ord-2a926841156e42a586ffe88e898c9c7a
Source dataset
uspto-grants-2012_05
Patent number
US08188114B2

Reaction notes

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