反应详情

A solution of 3,4-dichlorobenzoyl chloride (3.65 g, 17.4 mmol) was added dropwise under ice cooling to a solution of ethyl 3-[4-(4-aminophenoxy)phenyl]propionate (4.52 g, 15.9 mmol) and triethylamine (2.65 mL, 19.0 mmol) in THF (80 mL), and the resulting solution was stirred for 1 hour at the same temperature. Water was added to the reaction mixture, and extracted with ethyl acetate. The ethyl acetate layer was washed with a saturated sodium bicarbonate solution and brine. The ethyl acetate layer was dried over anhydrous magnesium sulfate and evaporated. The residue was recrystallized from water-containing ethanol to thereby yield 6.67 g of the title compound.

1. extractionextracted with ethyl acetate
2. washThe ethyl acetate layer was washed with a saturated sodium bicarbonate solution and brine
3. dry with materialThe ethyl acetate layer was dried over anhydrous magnesium sulfate
4. customevaporated
5. customThe residue was recrystallized from water-
6. additioncontaining ethanol to thereby yield 6.67 g of the title compound