Hydrochloric Acid → HCID 68526975, compound

HRID 1932526Notes

Reaction equation

HRID 1932526 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH:31]=[CH:32][C:33]=1[Cl:34])[C:5]([NH:7][C:8]1[CH:30]=[CH:29][C:11]([O:12][C:13]2[CH:18]=[CH:17][C:16]([N:19]3[CH2:24][CH2:23][CH:22]([O:25]COC)[CH2:21][CH2:20]3)=[CH:15][CH:14]=2)=[CH:10][CH:9]=1)=[O:6].Cl.C(=O)([O-])[O-].[K+].[K+]>C(O)C>[Cl:1][C:2]1[CH:3]=[C:4]([CH:31]=[CH:32][C:33]=1[Cl:34])[C:5]([NH:7][C:8]1[CH:30]=[CH:29][C:11]([O:12][C:13]2[CH:14]=[CH:15][C:16]([N:19]3[CH2:20][CH2:21][CH:22]([OH:25])[CH2:23][CH2:24]3)=[CH:17][CH:18]=2)=[CH:10][CH:9]=1)=[O:6]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 11430Potassium CarbonateHCID 68527382HCID 68527382, compound

Product 1

HCID 68526975HCID 68526975, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
60 °C

Procedure

To a solution of 1-{4-[4-(3,4-dichlorobenzoylamino)phenoxy]phenyl}-4-(methoxymethoxy)piperidine (5.50 g, 11.0 mmol) in ethanol (110 mL) was added 2 M hydrochloric acid (55 mL, 110 mmol), and the resulting solution was stirred for 8 hours at 60° C. To the resulting reaction solution was added potassium carbonate (16 g) at room temperature, and the solvent was evaporated under reduced pressure. Water (200 mL) was added to the residue. Precipitated crystals were collected by filtration, to thereby yield 5.0 g of the title compound.

Workup

  1. customTo the resulting reaction solution
  2. customthe solvent was evaporated under reduced pressure
  3. additionWater (200 mL) was added to the residue
  4. customPrecipitated crystals
  5. filtrationwere collected by filtration

Sources & evidence

ORD record
ord-68a6a4166c37448ca9d8bfe237440416
Source dataset
uspto-grants-2012_05
Patent number
US08188277B2

Reaction notes

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