反应详情

To a solution of N-[(R)-1-[3-(1-tert-butoxycarbonyl-4-piperidyl)-(E)-acryloyl]-3-piperidylcarbonyl]-β-alanine (1.64 g) in ethyl acetate (16 ml) was added 4N HCl in ethyl acetate (9.37 ml) at 0° C., and the reaction mixture was stirred for 2 hours at room temperature. The precipitates were filtered, washed with ether and resolved in water, neutralized with saturated aqueous NaHCO3, desalted by using the resin of HP-20 eluting with isopropanol-H2O (1:1), then freeze-dried to give N-[(R)-1-[3-(4-piperidyl)-(E)-acryloyl]-3-piperidylcarbonyl]-β-alanine as a white powder (690 mg).

1. filtrationThe precipitates were filtered
2. washwashed with ether
3. washeluting with isopropanol-H2O (1:1)
4. customfreeze-dried