反应详情

Chlorotriisopropylsilane (0.19 ml, 0.88 mmol) was added to a solution of methyl 2-(1,3-benzodioxol-5-yl)-2-[6-(hydroxymethyl)-1-methyl-1H-3-indolyl]acetate (from step (d), 260 mg, 0.74 mmol) and imidazole (100 mg, 1.47 mmol) in anhydrous dimethylformamide (3 ml). After 3 hours the mixture was partitioned between diethyl ether and water, the organic layer was separated and washed with water. The organic layer was dried (magnesium sulphate), and the solvent removed in vacuo. The residue was flash chromatographed (using 50% dichloromethane, 50% hexane as eluent) to give the subtitle compound (305 mg) as an oil.

1. customAfter 3 hours the mixture was partitioned between diethyl ether and water
2. customthe organic layer was separated
3. washwashed with water
4. dry with materialThe organic layer was dried (magnesium sulphate)
5. customthe solvent removed in vacuo
6. customchromatographed (using 50% dichloromethane, 50% hexane as eluent)