Benzenesulfonyl chloride → N-(3-Hydroxypropyl)benzenesulfonamide

HRID 1934638Notes

Reaction equation

[C:1]1([S:7](Cl)(=[O:9])=[O:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[NH2:11][CH2:12][CH2:13][CH2:14][OH:15]>>[OH:15][CH2:14][CH2:13][CH2:12][NH:11][S:7]([C:1]1[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1)(=[O:9])=[O:8]

Participants

Reactant 2

HCID 7369Benzenesulfonyl chloride

HCID 90863-Amino-1-propanol

Product 1

HCID 11333383N-(3-Hydroxypropyl)benzenesulfonamideYield 99.5%

Procedure

The preparation is carried out as in Example 1(a) from 353 g of benzenesulphonyl chloride (2 mol) and 157.7 g of 3-amino-1-propanol (2.1 mol). The amount obtained is 406.7 g, i.e. a yield of 99.5%.

Workup

customThe amount obtained

Sources & evidence

ORD record: ord-0e7c1d38ddb44b9f99813a23edd64106
Source dataset: uspto-grants-2002_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06384115B1

Reaction notes

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