Hydrochloric Acid → HCID 22467650, compound

HRID 1934687Notes

Reaction equation

HRID 1934687 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][CH2:11][CH:10]([NH:14][C:15]2[CH:34]=[CH:33][C:32]([N+:35]([O-:37])=[O:36])=[CH:31][C:16]=2[C:17]([NH:19][CH2:20][C:21]2[CH:26]=[CH:25][C:24]([O:27][CH3:28])=[C:23]([O:29][CH3:30])[CH:22]=2)=[O:18])[CH2:9]1)=O)(C)(C)C.[ClH:38]>C(OCC)(=O)C>[ClH:38].[CH3:30][O:29][C:23]1[CH:22]=[C:21]([CH:26]=[CH:25][C:24]=1[O:27][CH3:28])[CH2:20][NH:19][C:17](=[O:18])[C:16]1[CH:31]=[C:32]([N+:35]([O-:37])=[O:36])[CH:33]=[CH:34][C:15]=1[NH:14][CH:10]1[CH2:11][CH2:12][CH2:13][NH:8][CH2:9]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 22467512HCID 22467512, compound

Product 1

HCID 22467650HCID 22467650, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

A mixture of 2-[1-(tert-butoxycarbonyl)piperidin-3-ylamino]-N-(3,4-dimethoxybenzyl)-5-nitrobenzamide (190 mg) and 4 N hydrogenchloride solution in ethyl acetate (5 mL) was stirred for 2 hours at ambient temperature. The reaction mixture was concentrated in vacuo. The residual crystals were collected by filtration and washed with ethyl acetate to give N-(3,4-dimethoxybenzyl)-5-nitro-2-(piperidin-3-ylamino)benzamide hydrochloride (138 mg) as yellow crystals.

Workup

  1. concentrationThe reaction mixture was concentrated in vacuo
  2. filtrationThe residual crystals were collected by filtration
  3. washwashed with ethyl acetate

Sources & evidence

ORD record
ord-284aee7f8816459796d2c89a8457a175
Source dataset
uspto-grants-2002_05
Patent number
US06384080B1

Reaction notes

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