反应详情

温度

165 °C

A mixture of 30.6 g of 4-aminoveratrole and 43.2 g of diethyl ethoxymethylenemalonate was heated at 100 for 2 h and at 165° C. for 0.75 h. The intermediate thus obtained was dissolved in 600 ml of diphenyl ether, and the resulting solution was heated at reflux temperature for 2 h, cooled, and diluted with hexane. The resulting solid was filtered, washed with hexane followed by ether, and dried to provide the title compound as a brown solid, mp 275-285° C.

1. customThe intermediate thus obtained
2. temperaturethe resulting solution was heated
3. temperatureat reflux temperature for 2 h
4. temperaturecooled
5. filtrationThe resulting solid was filtered
6. washwashed with hexane
7. customdried